Research

A central research topic of our department is the analysis of the molecular reaction mechanisms of enzymes as nature’s catalysts. In this context, we study enzymes with vitamin-derived cofactors (incl. carbene chemistry), with metal ions, and Schiff base-forming enzymes. A particular focus is laid on the structural and kinetic characterization of reaction intermediates by high-resolution X-ray crystallography, steady-state and transient kinetic methods, NMR spectroscopy and theoretical studies. Knowledge about the reaction mechanism is exploited to redesign enzymes for biocatalytic applications and for drug design. More information can be found on our Homepage.

Affiliation

Albrecht-von-Haller-Institute for Plant Sciences
Georg-August University Göttingen

Phone +49(0)551 39-14430

Mail ktittma (at) uni-goettingen.de